TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling

TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting with Smad2-Smad4 complexes. We found that the complex structure of TGIF1–HD bound to the TGACA motif revealed a combined binding mode that involves the HD core and the major groove, on the one hand, and th...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Guca, Ewelina, Suñol, David, Ruiz, Lidia, Konkol, Agnieszka, Cordero, Jorge, Torner, Carles, Aragon, Eric, Martin-Malpartida, Pau, Riera, Antoni, Macias, Maria J
Format: Artigo
Language:Inglês
Published: Oxford University Press 2018
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6158717/
https://ncbi.nlm.nih.gov/pubmed/30060237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky680
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items