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TGIF1 homeodomain interacts with Smad MH1 domain and represses TGF-β signaling
TGIF1 is a multifunctional protein that represses TGF-β-activated transcription by interacting with Smad2-Smad4 complexes. We found that the complex structure of TGIF1–HD bound to the TGACA motif revealed a combined binding mode that involves the HD core and the major groove, on the one hand, and th...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6158717/ https://ncbi.nlm.nih.gov/pubmed/30060237 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky680 |
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