Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

TGF-β receptors phosphorylate SMAD2 and SMAD3 transcription factors, which then form heterotrimeric complexes with SMAD4 and cooperate with context-specific transcription factors to activate target genes. Here we provide biochemical and structural evidence showing that binding of SMAD2 to DNA depend...

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Vydáno v:Genes Dev
Hlavní autoři: Aragón, Eric, Wang, Qiong, Zou, Yilong, Morgani, Sophie M., Ruiz, Lidia, Kaczmarska, Zuzanna, Su, Jie, Torner, Carles, Tian, Lin, Hu, Jing, Shu, Weiping, Agrawal, Saloni, Gomes, Tiago, Márquez, José A., Hadjantonakis, Anna-Katerina, Macias, Maria J., Massagué, Joan
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2019
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6824466/
https://ncbi.nlm.nih.gov/pubmed/31582430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.330837.119
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