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Cytoplasmic initiation of cisplatin cytotoxicity
The mechanism of action of cisplatin as a chemotherapeutic agent has been attributed to DNA binding, while its mechanism of action as a nephrotoxin is unresolved. Only ∼1% of intracellular cisplatin interacts with DNA, primarily forming intrastrand cross-linked adducts, and many studies have implica...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2494516/ https://ncbi.nlm.nih.gov/pubmed/18400869 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00593.2007 |
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