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Dependence of Cisplatin-Induced Cell Death In Vitro and In Vivo on Cyclin-Dependent Kinase 2

Cisplatin is one of the most effective chemotherapeutics, but its usefulness is limited by its toxicity to normal tissues, including cells of the kidney proximal tubule. The purpose of these studies was to determine the mechanism of cisplatin cytotoxicity. It was shown in vivo that cisplatin adminis...

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Detalhes bibliográficos
Main Authors: Price, Peter M., Yu, Fang, Kaldis, Philipp, Aleem, Eiman, Nowak, Grażyna, Safirstein, Robert L., Megyesi, Judit
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698291/
https://ncbi.nlm.nih.gov/pubmed/16914540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2006020162
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