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Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase

Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. A Cdk2 mutant (Cdk2-F80G) was designed in which the ATP-binding pocket was altered. When expressed in mouse kidney cells, this protein was kinase inactive, did not inhibit endogenous Cdk2, but prot...

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Detalhes bibliográficos
Main Authors: Hodeify, Rawad, Megyesi, Judit, Tarcsafalvi, Adel, Safirstein, Robert L., Price, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904183/
https://ncbi.nlm.nih.gov/pubmed/20444741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00151.2010
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