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Protection of cisplatin cytotoxicity by an inactive cyclin-dependent kinase
Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. A Cdk2 mutant (Cdk2-F80G) was designed in which the ATP-binding pocket was altered. When expressed in mouse kidney cells, this protein was kinase inactive, did not inhibit endogenous Cdk2, but prot...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Physiological Society
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2904183/ https://ncbi.nlm.nih.gov/pubmed/20444741 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00151.2010 |
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