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Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity
Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. We found that an 18-kDa protein identified by mass spectrometry as p21(WAF1/Cip1) was phosphorylated by Cdk2 starting 12 h after cisplatin exposure. The analysis showed it was phosphorylated at ser...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2011
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3094048/ https://ncbi.nlm.nih.gov/pubmed/21325496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00507.2010 |
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