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Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity

Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. We found that an 18-kDa protein identified by mass spectrometry as p21(WAF1/Cip1) was phosphorylated by Cdk2 starting 12 h after cisplatin exposure. The analysis showed it was phosphorylated at ser...

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Detalhes bibliográficos
Main Authors: Hodeify, Rawad, Tarcsafalvi, Adel, Megyesi, Judit, Safirstein, Robert L., Price, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094048/
https://ncbi.nlm.nih.gov/pubmed/21325496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00507.2010
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