The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice

The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to...

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Bibliografski detalji
Glavni autori: Bousejra-El Garah, Fatima, Claparols, Catherine, Benoit-Vical, Françoise, Meunier, Bernard, Robert, Anne
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Mechanisms of Action: Physiological Effects
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2493093/
https://ncbi.nlm.nih.gov/pubmed/18559651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00165-08
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