Trioxaquines and Heme-Artemisinin Adducts Inhibit the In Vitro Formation of Hemozoin Better than Chloroquine

Trioxaquines, potential antimalarial agents, and heme-artemisinin adducts, resulting from the alkylation of heme by artemisinin, were evaluated as inhibitors of β-hematin formation in 10 M acetate medium at pH 5.

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Bibliographic Details
Main Authors: Loup, Christophe, Lelièvre, Joël, Benoit-Vical, Françoise, Meunier, Bernard
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043280/
https://ncbi.nlm.nih.gov/pubmed/17698628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00239-07
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