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The Antimalarial Trioxaquine DU1301 Alkylates Heme in Malaria-Infected Mice
The in vivo alkylation of heme by the antimalarial trioxaquine DU1301 afforded covalent heme-drug adducts that were detected in the spleens of Plasmodium sp.-infected mice. This result indicates that the alkylation capacities of trioxaquines in mammals infected with Plasmodium strains are similar to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2493093/ https://ncbi.nlm.nih.gov/pubmed/18559651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00165-08 |
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