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Trioxaquine PA1259 Alkylates Heme in the Blood-Feeding Parasite Schistosoma mansoni
Trioxaquine PA1259 is an efficient drug on larval- and adult-stage schistosomes, able to alkylate heme inside worms treated with it, leading to the formation of covalent heme-drug adducts. Such a mechanism, similar to one reported for other trioxaquines in Plasmodium, indicates that heme may be a co...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3088258/ https://ncbi.nlm.nih.gov/pubmed/21300841 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00082-11 |
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