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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

Zebrafish carrying heterozygous mutations for 17 different ribosomal protein (rp) genes are prone to developing malignant peripheral nerve sheath tumors (MPNSTs), a tumor type that is seldom seen in laboratory strains of zebrafish. Interestingly, the same rare tumor type arises in zebrafish that are...

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Bibliographic Details
Main Authors: MacInnes, Alyson W., Amsterdam, Adam, Whittaker, Charles A., Hopkins, Nancy, Lees, Jacqueline A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2008
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492501/
https://ncbi.nlm.nih.gov/pubmed/18641120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805036105
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