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Loss of p53 synthesis in zebrafish tumors with ribosomal protein gene mutations

Zebrafish carrying heterozygous mutations for 17 different ribosomal protein (rp) genes are prone to developing malignant peripheral nerve sheath tumors (MPNSTs), a tumor type that is seldom seen in laboratory strains of zebrafish. Interestingly, the same rare tumor type arises in zebrafish that are...

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Detalhes bibliográficos
Main Authors: MacInnes, Alyson W., Amsterdam, Adam, Whittaker, Charles A., Hopkins, Nancy, Lees, Jacqueline A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2492501/
https://ncbi.nlm.nih.gov/pubmed/18641120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0805036105
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