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Many Ribosomal Protein Mutations Are Associated With Growth Impairment and Tumor Predisposition in Zebrafish

We have characterized 28 zebrafish lines with heterozygous mutations in ribosomal protein (rp) genes, and found that 17 of these are prone to develop zebrafish malignant peripheral nerve sheath tumors (zMPNST). Heterozygotes from the vast majority of tumor-prone rp lines were found to be growth-impa...

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Autors principals: Lai, Kevin, Amsterdam, Adam, Farrington, Sarah, Bronson, Roderick T., Hopkins, Nancy, Lees, Jacqueline A.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2682537/
https://ncbi.nlm.nih.gov/pubmed/19097187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvdy.21815
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