An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain.
The molecular basis of the temperature-sensitive (ts) phenotype of P3/Sabin, the type 3 vaccine strain of poliovirus, was investigated in light of the known correlation between ts and attenuation phenotypes. A phenylalanine at residue 91 of the capsid protein VP3 was a major determinant of both phen...
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| Udgivet i: | J Virol |
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| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Microbiology (ASM)
1991
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249000/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1654440/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.10.5225-5231.1991 |
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