An assembly defect as a result of an attenuating mutation in the capsid proteins of the poliovirus type 3 vaccine strain.

The molecular basis of the temperature-sensitive (ts) phenotype of P3/Sabin, the type 3 vaccine strain of poliovirus, was investigated in light of the known correlation between ts and attenuation phenotypes. A phenylalanine at residue 91 of the capsid protein VP3 was a major determinant of both phen...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Macadam, A J, Ferguson, G, Arnold, C, Minor, P D
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC249000/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1654440/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.65.10.5225-5231.1991
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