A Group B Coxsackievirus/Poliovirus 5′ Nontranslated Region Chimera Can Act as an Attenuated Vaccine Strain in Mice

The linear, single-stranded enterovirus RNA genome is flanked at either end with a nontranslated region (NTR). By replacing the entire 5′ NTR of coxsackievirus B3 (CVB3) with that from type 1 poliovirus, a progeny virus was obtained following transfection of HeLa cells. The chimeric virus, CPV/49, r...

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Bibliografiske detaljer
Main Authors: Chapman, Nora M., Ragland, Anna, Leser, J. Smith, Höfling, Katja, Willian, Sandra, Semler, Bert L., Tracy, Steven
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Vaccines and Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC111918/
https://ncbi.nlm.nih.gov/pubmed/10756016
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