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A Group B Coxsackievirus/Poliovirus 5′ Nontranslated Region Chimera Can Act as an Attenuated Vaccine Strain in Mice

The linear, single-stranded enterovirus RNA genome is flanked at either end with a nontranslated region (NTR). By replacing the entire 5′ NTR of coxsackievirus B3 (CVB3) with that from type 1 poliovirus, a progeny virus was obtained following transfection of HeLa cells. The chimeric virus, CPV/49, r...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Chapman, Nora M., Ragland, Anna, Leser, J. Smith, Höfling, Katja, Willian, Sandra, Semler, Bert L., Tracy, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111918/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756016/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4047-4056.2000
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