A Group B Coxsackievirus/Poliovirus 5′ Nontranslated Region Chimera Can Act as an Attenuated Vaccine Strain in Mice

The linear, single-stranded enterovirus RNA genome is flanked at either end with a nontranslated region (NTR). By replacing the entire 5′ NTR of coxsackievirus B3 (CVB3) with that from type 1 poliovirus, a progeny virus was obtained following transfection of HeLa cells. The chimeric virus, CPV/49, r...

Description complète

Détails bibliographiques

Publié dans:	J Virol
Auteurs principaux:	Chapman, Nora M., Ragland, Anna, Leser, J. Smith, Höfling, Katja, Willian, Sandra, Semler, Bert L., Tracy, Steven
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Vaccines and Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111918/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10756016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.9.4047-4056.2000
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!