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v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: Multiple interference with the isoprenoid pathway

The isoprenoid pathway in FRTL-5 thyroid cells was found to be deeply altered on transformation with v-K-ras. A dramatic overall reduction of protein prenylation was found in v-K-ras-transformed cells in comparison with the parent FRTL-5 cells, as shown by labeling cells with [(3)H]mevalonic acid. T...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Laezza, Chiara, Di Marzo, Vincenzo, Bifulco, Maurizio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24873/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9811854/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.23.13646
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