Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia

Faithful modeling of mixed lineage leukemia in murine cells has been difficult to achieve. We show that expression of MLL-AF9 in human CD34+ cells induces acute myeloid, lymphoid or mixed lineage leukemia in immunodeficient mice. Some leukemia stem cells (LSC) were multipotent and could be lineage d...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Wei, Junping, Wunderlich, Mark, Fox, Catherine, Alvarez, Sara, Cigudosa, Juan C., Wilhelm, Jamie S., Zheng, Yi, Cancelas, Jose A., Gu, Yi, Jansen, Michael, DiMartino, Jorge F., Mulloy, James C.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2008
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2486365/
https://ncbi.nlm.nih.gov/pubmed/18538732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.04.020
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