Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine

Recently, macroautophagy/autophagy has emerged as a promising target in various types of solid tumor treatment. However, the impact of autophagy on acute myeloid leukemia (AML) maintenance and the validity of autophagy as a viable target in AML therapy remain unclear. Here we show that Kmt2a/Mll-Mll...

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Podrobná bibliografie
Vydáno v:Autophagy
Hlavní autoři: Chen, Xiaoyi, Clark, Jason, Wunderlich, Mark, Fan, Cuiqing, Davis, Ashley, Chen, Song, Guan, Jun-Lin, Mulloy, James C., Kumar, Ashish, Zheng, Yi
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2017
Témata:
Translational Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446057/
https://ncbi.nlm.nih.gov/pubmed/28282266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1287652
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