Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

The Rac family of small Rho GTPases coordinates diverse cellular functions in hematopoietic cells including adhesion, migration, cytoskeleton rearrangements, gene transcription, proliferation, and survival. The integrity of Rac signaling has also been found to critically regulate cellular functions...

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Bibliografische gegevens
Hoofdauteurs: Mizukawa, Benjamin, Wei, Junping, Shrestha, Mahesh, Wunderlich, Mark, Chou, Fu-Sheng, Griesinger, Andrea, Harris, Chad E., Kumar, Ashish R., Zheng, Yi, Williams, David A., Mulloy, James C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2011
Onderwerpen:
Myeloid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217406/
https://ncbi.nlm.nih.gov/pubmed/21940819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-351817
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