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Activation of Gαi3 triggers cell migration via regulation of GIV

During migration, cells must couple direction sensing to signal transduction and actin remodeling. We previously identified GIV/Girdin as a Gαi3 binding partner. We demonstrate that in mammalian cells Gαi3 controls the functions of GIV during cell migration. We find that Gαi3 preferentially localize...

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Bibliografische gegevens
Hoofdauteurs: Ghosh, Pradipta, Garcia-Marcos, Mikel, Bornheimer, Scott J., Farquhar, Marilyn G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483528/
https://ncbi.nlm.nih.gov/pubmed/18663145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200712066
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