Extensive meiotic asynapsis in mice antagonises meiotic silencing of unsynapsed chromatin and consequently disrupts meiotic sex chromosome inactivation

Chromosome synapsis during zygotene is a prerequisite for the timely homologous recombinational repair of meiotic DNA double-strand breaks (DSBs). Unrepaired DSBs are thought to trigger apoptosis during midpachytene of male meiosis if synapsis fails. An early pachytene response to asynapsis is meiot...

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Bibliografiske detaljer
Main Authors: Mahadevaiah, Shantha K., Bourc'his, Déborah, de Rooij, Dirk G., Bestor, Timothy H., Turner, James M.A., Burgoyne, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2008
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483523/
https://ncbi.nlm.nih.gov/pubmed/18663141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200710195
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