Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes

During spermatogenesis, germ cells that fail to synapse their chromosomes or fail to undergo meiotic sex chromosome inactivation (MSCI) are eliminated via apoptosis during mid-pachytene. Previous work showed that Y-linked genes Zfy1 and Zfy2 act as ‘executioners’ for this checkpoint, and that wrongf...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Vernet, Nadège, Mahadevaiah, Shantha K., de Rooij, Dirk G., Burgoyne, Paul S., Ellis, Peter J. I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418838/
https://ncbi.nlm.nih.gov/pubmed/27742779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw344
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