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Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes

During spermatogenesis, germ cells that fail to synapse their chromosomes or fail to undergo meiotic sex chromosome inactivation (MSCI) are eliminated via apoptosis during mid-pachytene. Previous work showed that Y-linked genes Zfy1 and Zfy2 act as ‘executioners’ for this checkpoint, and that wrongf...

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Dettagli Bibliografici
Pubblicato in:Hum Mol Genet
Autori principali: Vernet, Nadège, Mahadevaiah, Shantha K., de Rooij, Dirk G., Burgoyne, Paul S., Ellis, Peter J. I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418838/
https://ncbi.nlm.nih.gov/pubmed/27742779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw344
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