Zfy genes are required for efficient meiotic sex chromosome inactivation (MSCI) in spermatocytes

During spermatogenesis, germ cells that fail to synapse their chromosomes or fail to undergo meiotic sex chromosome inactivation (MSCI) are eliminated via apoptosis during mid-pachytene. Previous work showed that Y-linked genes Zfy1 and Zfy2 act as ‘executioners’ for this checkpoint, and that wrongf...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Vernet, Nadège, Mahadevaiah, Shantha K., de Rooij, Dirk G., Burgoyne, Paul S., Ellis, Peter J. I.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5418838/
https://ncbi.nlm.nih.gov/pubmed/27742779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw344
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