pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

The crystal structure of Escherichia coli ketopantoate reductase in complex with 2′-monophosphoadenosine 5′-diphosphoribose, a fragment of NADP(+) that lacks the nicotinamide ring, is reported. The ligand is bound at the enzyme active site in the opposite orientation to that observed for NADP(+), wi...

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Hlavní autoři: Ciulli, Alessio, Lobley, Carina M. C., Tuck, Kellie L., Smith, Alison G., Blundell, Tom L., Abell, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2007
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483484/
https://ncbi.nlm.nih.gov/pubmed/17242510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444906044465
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