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Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus
Ketopantoate reductase (KPR) catalyzes the NADPH-dependent production of pantoate, an essential precursor in the biosynthesis of coenzyme A. Previous structural studies have been limited to Escherichia coli KPR, a monomeric enzyme that follows a sequential ordered mechanism. Here we report the cryst...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4668926/ https://ncbi.nlm.nih.gov/pubmed/25946571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00174 |
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