Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

INTRODUCTION: Subchondral bone alterations represent an essential component of osteoarthritis (OA). Modifying the abnormal subchondral bone metabolism may be indicated to treat OA. We investigated the effect of diacerein and rhein on the changes occurring in subchondral bone during OA. To this end,...

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Bibliographic Details
Main Authors: Boileau, Christelle, Tat, Steeve Kwan, Pelletier, Jean-Pierre, Cheng, Saranette, Martel-Pelletier, Johanne
Format: Artigo
Language:Inglês
Published: BioMed Central 2008
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483463/
https://ncbi.nlm.nih.gov/pubmed/18578867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2444
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