Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

INTRODUCTION: Subchondral bone alterations represent an essential component of osteoarthritis (OA). Modifying the abnormal subchondral bone metabolism may be indicated to treat OA. We investigated the effect of diacerein and rhein on the changes occurring in subchondral bone during OA. To this end,...

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Main Authors: Boileau, Christelle, Tat, Steeve Kwan, Pelletier, Jean-Pierre, Cheng, Saranette, Martel-Pelletier, Johanne
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483463/
https://ncbi.nlm.nih.gov/pubmed/18578867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2444
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