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Diacerein inhibits the synthesis of resorptive enzymes and reduces osteoclastic differentiation/survival in osteoarthritic subchondral bone: a possible mechanism for a protective effect against subchondral bone remodelling

INTRODUCTION: Subchondral bone alterations represent an essential component of osteoarthritis (OA). Modifying the abnormal subchondral bone metabolism may be indicated to treat OA. We investigated the effect of diacerein and rhein on the changes occurring in subchondral bone during OA. To this end,...

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書誌詳細
主要な著者: Boileau, Christelle, Tat, Steeve Kwan, Pelletier, Jean-Pierre, Cheng, Saranette, Martel-Pelletier, Johanne
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483463/
https://ncbi.nlm.nih.gov/pubmed/18578867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2444
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