RGT, a synthetic peptide corresponding to the integrin β3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin αIIbβ3 with Src kinase

Mutational analysis has established that the cytoplasmic tail of the integrin β3 subunit binds c-Src (termed as Src in this study) and is critical for bidirectional integrin signaling. Here we show in washed human platelets that a cell-permeable, myristoylated RGT peptide (myr-RGT) corresponding to...

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Detalhes bibliográficos
Main Authors: Su, Xiaoyu, Mi, Jianqing, Yan, Jinsong, Flevaris, Panagiotis, Lu, Yuanjing, Liu, Hongchen, Ruan, Zheng, Wang, Xuefeng, Kieffer, Nelly, Chen, Saijuan, Du, Xiaoping, Xi, Xiaodong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481538/
https://ncbi.nlm.nih.gov/pubmed/18398066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-09-110437
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