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Heparin promotes platelet responsiveness by potentiating αIIbβ3-mediated outside-in signaling
Unfractionated heparin (UFH) is a widely used anticoagulant that has long been known to potentiate platelet responses to subthreshold doses of platelet agonists. UFH has been reported to bind and induce modest conformational changes in the major platelet integrin, αIIbβ3, and induce minor changes in...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2011
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100701/ https://ncbi.nlm.nih.gov/pubmed/21368290 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307751 |
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