Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine.
The poliovirus type 3 Sabin oral poliovirus vaccine strain P3/Leon/12a1b differs in nucleotide sequence from its neurovirulent progenitor P3/Leon/37 by just 10 point mutations. The contribution of each mutation to the attenuation phenotype of the vaccine strain was determined by the construction of...
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| Gepubliceerd in: | J Virol |
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| Hoofdauteurs: | , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
American Society for Microbiology (ASM)
1989
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536836/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.3.1338-1344.1989 |
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