Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine.

The poliovirus type 3 Sabin oral poliovirus vaccine strain P3/Leon/12a1b differs in nucleotide sequence from its neurovirulent progenitor P3/Leon/37 by just 10 point mutations. The contribution of each mutation to the attenuation phenotype of the vaccine strain was determined by the construction of...

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Autores principales: Westrop, G D, Wareham, K A, Evans, D M, Dunn, G, Minor, P D, Magrath, D I, Taffs, F, Marsden, S, Skinner, M A, Schild, G C
Formato: Artigo
Lenguaje:Inglês
Publicado: 1989
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC247831/
https://ncbi.nlm.nih.gov/pubmed/2536836
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