Genetic basis of attenuation of the Sabin type 3 oral poliovirus vaccine.

The poliovirus type 3 Sabin oral poliovirus vaccine strain P3/Leon/12a1b differs in nucleotide sequence from its neurovirulent progenitor P3/Leon/37 by just 10 point mutations. The contribution of each mutation to the attenuation phenotype of the vaccine strain was determined by the construction of...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Westrop, G D, Wareham, K A, Evans, D M, Dunn, G, Minor, P D, Magrath, D I, Taffs, F, Marsden, S, Skinner, M A, Schild, G C
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247831/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2536836/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.3.1338-1344.1989
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