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Asp-286----Asn-286 in polyomavirus large T antigen relaxes the specificity of binding to the polyomavirus origin.

We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replicatio...

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Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Tang, W J, Folk, W R
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 1989
Teme:
Online dostop:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247678/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2535730/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.1.242-249.1989
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