Asp-286----Asn-286 in polyomavirus large T antigen relaxes the specificity of binding to the polyomavirus origin.
We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replicatio...
Guardat en:
| Publicat a: | J Virol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1989
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247678/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2535730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.1.242-249.1989 |
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