Asp-286----Asn-286 in polyomavirus large T antigen relaxes the specificity of binding to the polyomavirus origin.
We isolated revertants of a polyomavirus whose origin of DNA replication contains a point mutation in the palindrome to which large T antigen binds. Four independent second-site revertants contain an Asp-286----Asn-286 substitution in large T antigen. This mutant large T antigen activates replicatio...
Guardado en:
| Publicado en: | J Virol |
|---|---|
| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Microbiology (ASM)
1989
|
| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC247678/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2535730/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.63.1.242-249.1989 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|