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Binding of Polyomavirus Small T Antigen to Protein Phosphatase 2A Is Required for Elimination of p27 and Support of S-Phase Induction in Concert with Large T Antigen

Although polyomavirus large T antigen readily transactivates S-phase-specific enzymes in serum-starved Swiss 3T3 mouse fibroblasts, it is incapable by itself to efficiently drive such cells into S phase. We describe here that this inability correlates with a weak proficiency of the viral protein to...

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Библиографические подробности
Главные авторы: Schüchner, Stefan, Wintersberger, Erhard
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 1999
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC112961/
https://ncbi.nlm.nih.gov/pubmed/10516035
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