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The RNA Polymerase II Trigger Loop Functions in Substrate Selection and is Directly Targeted by α-amanitin
Structural, biochemical and genetic studies have led to proposals that a mobile element of multi-subunit RNA polymerases, the Trigger Loop (TL), plays a critical role in catalysis and can be targeted by antibiotic inhibitors. Here we present evidence that the Saccharomyces cerevisiae RNA Polymerase...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2475549/ https://ncbi.nlm.nih.gov/pubmed/18538653 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.04.023 |
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