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Structural basis of transcription: role of the trigger loop in substrate specificity and catalysis

New structures of RNA polymerase II (pol II) transcribing complexes reveal a likely key to transcription. The trigger loop swings beneath a correct nucleoside triphosphate (NTP) in the nucleotide addition site, closing off the active center, and forming an extensive network of interactions with the...

詳細記述

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書誌詳細
主要な著者: Wang, Dong, Bushnell, David A., Westover, Kenneth D., Kaplan, Craig D., Kornberg, Roger D.
フォーマット: Artigo
言語:Inglês
出版事項: 2006
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1876690/
https://ncbi.nlm.nih.gov/pubmed/17129781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.11.023
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