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Structural basis of transcription: α-Amanitin–RNA polymerase II cocrystal at 2.8 Å resolution

The structure of RNA polymerase II in a complex with the inhibitor α-amanitin has been determined by x-ray crystallography. The structure of the complex indicates the likely basis of inhibition and gives unexpected insight into the transcription mechanism.

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Detalhes bibliográficos
Main Authors: Bushnell, David A., Cramer, Patrick, Kornberg, Roger D.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122170/
https://ncbi.nlm.nih.gov/pubmed/11805306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251664698
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