Mutations at arginine 352 alter the pore architecture of CFTR

Arginine 352 (R352) in CFTR’s sixth transmembrane domain previously was reported to form an anion/cation selectivity filter and to provide positive charge in the intracellular vestibule. However, mutations at this site have non-specific effects, such as inducing susceptibility of endogenous cysteine...

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Bibliografiske detaljer
Main Authors: Cui, Guiying, Zhang, Zhi-Ren, O’Brien, Andrew R.W., Song, Binlin, McCarty, Nael A.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474774/
https://ncbi.nlm.nih.gov/pubmed/18421494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00232-008-9105-9
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