CFTR: A Cysteine at Position 338 in TM6 Senses a Positive Electrostatic Potential in the Pore

We investigated the accessibility to protons and thiol-directed reagents of a cysteine substituted at position 338 in transmembrane segment 6 (TM6) of CFTR to test the hypothesis that T338 resides in the pore. Xenopus oocytes expressing T338C CFTR exhibited pH-dependent changes in g(Cl) and I-V shap...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Liu, Xuehong, Zhang, Zhi-Ren, Fuller, Matthew D., Billingsley, Joshua, McCarty, Nael A., Dawson, David C.
Formato: Artigo
Idioma:Inglês
Publicado: Biophysical Society 2004
Assuntos:
Channels, Receptors, and Electrical Signaling
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304894/
https://ncbi.nlm.nih.gov/pubmed/15361410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.050534
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares