CFTR: Ligand Exchange between a Permeant Anion ([Au(CN)(2)](−)) and an Engineered Cysteine (T338C) Blocks the Pore

Previous attempts to identify residues that line the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel have utilized cysteine-substituted channels in conjunction with impermeant, thiol-reactive reagents like MTSET(+) and MTSES(−). We report here that the permean...

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Detalhes bibliográficos
Main Authors: Serrano, José R., Liu, Xuehong, Borg, Erik R., Alexander, Christopher S., Shaw, C. Frank, Dawson, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Channels, Receptors, and Electrical Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544293/
https://ncbi.nlm.nih.gov/pubmed/16766608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.078899
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