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Three charged amino acids in extracellular loop 1 are involved in maintaining the outer pore architecture of CFTR
The cystic fibrosis (CF) transmembrane conductance regulator (CFTR) bears six extracellular loops (ECL1–6); ECL1 is the site of several mutations associated with CF. Mutation R117H has been reported to reduce current amplitude, whereas D110H, E116K, and R117C/L/P may impair channel stability. We hyp...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4113900/ https://ncbi.nlm.nih.gov/pubmed/25024266 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201311122 |
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