Soluble receptor-mediated selective inhibition of VEGFR and PDGFRβ signaling during physiologic and tumor angiogenesis

The simultaneous targeting of both endothelial cells and pericytes via inhibition of VEGF receptor (VEGFR) and PDGFβ receptor (PDGFRβ) signaling, respectively, has been proposed to enhance the efficacy of antiangiogenic tumor therapy. Clinical and preclinical modeling of combined VEGFR and PDGFRβ si...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kuhnert, Frank, Tam, Betty Y. Y., Sennino, Barbara, Gray, John T., Yuan, Jenny, Jocson, Angeline, Nayak, Nihar R., Mulligan, Richard C., McDonald, Donald M., Kuo, Calvin J.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2008
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474564/
https://ncbi.nlm.nih.gov/pubmed/18632559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803194105
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