Soluble receptor-mediated selective inhibition of VEGFR and PDGFRβ signaling during physiologic and tumor angiogenesis

The simultaneous targeting of both endothelial cells and pericytes via inhibition of VEGF receptor (VEGFR) and PDGFβ receptor (PDGFRβ) signaling, respectively, has been proposed to enhance the efficacy of antiangiogenic tumor therapy. Clinical and preclinical modeling of combined VEGFR and PDGFRβ si...

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Autori principali: Kuhnert, Frank, Tam, Betty Y. Y., Sennino, Barbara, Gray, John T., Yuan, Jenny, Jocson, Angeline, Nayak, Nihar R., Mulligan, Richard C., McDonald, Donald M., Kuo, Calvin J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474564/
https://ncbi.nlm.nih.gov/pubmed/18632559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803194105
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