Soluble receptor-mediated selective inhibition of VEGFR and PDGFRβ signaling during physiologic and tumor angiogenesis

The simultaneous targeting of both endothelial cells and pericytes via inhibition of VEGF receptor (VEGFR) and PDGFβ receptor (PDGFRβ) signaling, respectively, has been proposed to enhance the efficacy of antiangiogenic tumor therapy. Clinical and preclinical modeling of combined VEGFR and PDGFRβ si...

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Autors principals: Kuhnert, Frank, Tam, Betty Y. Y., Sennino, Barbara, Gray, John T., Yuan, Jenny, Jocson, Angeline, Nayak, Nihar R., Mulligan, Richard C., McDonald, Donald M., Kuo, Calvin J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2008
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474564/
https://ncbi.nlm.nih.gov/pubmed/18632559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803194105
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