Proteolytic processing of the Alzheimer disease-associated presenilin-1 generates an in vivo substrate for protein kinase C

The majority of familial Alzheimer disease mutations are linked to the recently cloned presenilin (PS) genes, which encode two highly homologous proteins (PS-1 and PS-2). It was shown that the full-length PS-2 protein is phosphorylated constitutively within its N-terminal domain by casein kinases, w...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Walter, Jochen, Grünberg, Jürgen, Capell, Anja, Pesold, Brigitte, Schindzielorz, Alice, Citron, Martin, Mendla, Klaus, George-Hyslop, Peter St, Multhaup, Gerd, Selkoe, Dennis J., Haass, Christian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC24681/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9144240/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.10.5349
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