Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb β(s)-globin yeast artificial chromosome: A mouse model of sickle cell anemia

Sickle cell anemia (SCA) and thalassemia are among the most common genetic diseases worldwide. Current approaches to the development of murine models of SCA involve the elimination of functional murine α- and β-globin genes and substitution with human α and β(s) transgenes. Recently, two groups have...

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Autors principals: Chang, Judy C., Lu, Ronghua, Lin, Chin, Xu, Shan-Mei, Kan, Yuet Wai, Porcu, Susanna, Carlson, Elaine, Kitamura, Michael, Yang, Suya, Flebbe-Rehwaldt, Linda, Gaensler, Karin M. L.
Format: Artigo
Idioma:Inglês
Publicat: The National Academy of Sciences 1998
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC24545/
https://ncbi.nlm.nih.gov/pubmed/9843985
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